We recently published an article in Nature Reviews Cancer describing the cfDNA fragmentome, and the universe of cancer-related alterations that it can capture using AI and accessible, low-coverage whole genome sequencing. We have previously defined the cfDNA fragmentome as the genome-wide compendium of cfDNA fragments found in the circulation, providing an integrated view of an individual’s genomic, epigenomic and chromatin state. Congratulations to Dan and our team on this great resource highlighting the potential for cfDNA fragmentomes to revolutionize the early detection and monitoring of cancer!
Bruhm DC, Vulpescu NA, Foda Z, Phallen J, Scharpf RB, Velculescu VE. Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection. Nature Reviews Cancer 25, 341–358. 2025 Mar 04. doi: 10.1038/s41568-025-00795-x. Article