We recently developed a novel blood test to detect brain tumors which was just published in Cancer Discovery! These are some of the hardest to find tumors and historically have been thought near-impossible to detect in the circulation, but this novel test uses our lab’s ARTEMIS and DELFI approaches to detect genome-wide changes to cfDNA arising from both brain and immune cells. Congratulations to Dimitrios, Noushin and all members of our team on this great effort to change paradigms for brain cancer detection!
Mathios D, Niknafs N, Annapragada AV, Bobeff EJ, Chiao EJ, Boyapati K, Boyapati K, Short S, Bartolomucci AL, Cristiano S, Koul S, Vulpescu NA, Ferreira L, Medina JE, Bruhm DC, Adleff V, Podstawka M, Stanisławska P, Park CK, Huang J, Gallia GL, Brem H, Mukherjee D, Caplan JM, Weingart J, Jackson CM, Lim M, Phallen J, Scharpf RB, Velculescu VE. Detection of brain cancer using genome-wide cell-free DNA fragmentomes. Cancer Discovery. 2025 Apr 29. doi: 10.1158/2159-8290.CD-25-0074. Epub ahead of print. PMID: 40299319. Article | Press.